About Gut-Research

Research group within the Tytgat Institute for Liver and Intestinal Research in Amsterdam

Service Details

Service Overview

At Gut-Research, we specialize in advancing the understanding and treatment of gastrointestinal diseases through innovative research and clinical collaboration. Our expert team and state-of-the-art facilities enable us to offer high-quality, impactful services across four main areas: intestinal microbiota and health, inflammatory bowel disease (IBD) and personalized medicine, colorectal cancer treatment, and intestinal health for newborns.

Our Capabilities

Gut-Research is equipped with cutting-edge technology and a team of leading scientists and clinicians. Our capabilities include advanced research techniques, extensive biobanking, and robust preclinical and clinical trial support. We specialize in areas such as microbiota analysis, inflammatory bowel disease (IBD) research, irritable bowel syndrome (IBS) studies, and pediatric gastroenterology. Our collaborative approach and dedication to excellence make us a trusted partner in gastrointestinal research.

We study the intricate interactions between gut microbiota and human health, focusing on diseases such as inflammatory bowel disease and colorectal cancer. Our services include comprehensive microbiota analysis, using cutting-edge sequencing technologies and bioinformatics to understand microbial influence on gut health and to develop innovative treatments. We collaborate with the HoloMicroBiome and METAHEALTH projects, as well as the company AIBiomics, to advance rapid microbiome testing and analysis.
Our research group has been at the forefront of IBD treatment, leading breakthroughs such as the introduction of anti-TNF therapy for Crohn’s disease. We offer personalized treatment development, leveraging advanced techniques like single-cell sequencing and Mass Cytometry. Our research models and biobank facilities support detailed investigation into the pathogenesis of IBD, enabling us to offer tailored clinical trial support. Ongoing projects like the Methylomic and AMFIBIO trials are focused on identifying biomarkers for precision medicine.
We conduct preclinical and clinical research into surgical complications and wound healing, particularly focusing on anastomotic leakage (AL), a common complication after colorectal surgery. Our goal is to uncover the cellular and molecular mechanisms of wound healing to improve recovery rates and post-operative care for cancer patients. Current projects, such as MICROPIAL and METARYL, investigate the role of microbiota and nutritional components in healing post-surgery.
We focus on early life nutrition and its impact on the intestinal health of neonates and preterm infants. Our research explores the critical role of breast milk in preventing diseases such as sepsis, pneumonia, and obesity, while studying mechanisms behind gut development. The EMMA Center for Personalized Medicine and the KinderBuik Centrum are key collaborators in our efforts to improve neonatal outcomes. Projects like GROWTH focus on understanding intestinal development in preterm infants.

Partner With Us

At Gut-Research, we are committed to driving innovation in gastrointestinal research through collaboration with academic institutions, healthcare providers, and industry partners. We invite you to explore partnership opportunities and learn how our expertise can support your research and clinical development goals.