Team Lead/Postdoctoral Scientist

'Immunology of pediatric intestinal disease' (36 hrs)
Develop a dynamic and collaborative research program that focuses on intestinal diseases by making use of state-of-the-art bioinformatic tools.

About the Role

As Team Lead Postdoctoral Scientist/Assistant Professor you will harness (big) omics data and combine it with current knowledge of immunology to better understand intestinal diseases. Specifically, we are looking for an advanced senior scientist/young group leader to develop a dynamic and collaborative research program that focusses on pediatric intestinal diseases and complications of intestinal surgery. You will be using state-of-the-art bioinformatic tools to study aspects of disease progression and treatment success.

The Postdoc Team Lead should have a strong background in both immunology and bioinformatics and be willing to develop his/her own research line within the Department of Pediatric Surgery, and the Tytgat Institute, attached to the Department of Gastroenterology. The successful candidate will be expected to establish and maintain a vigorous program of independent, externally funded research, and to contribute to undergraduate and graduate teaching programs.

The functions include, in varying proportions:

  • a) research,
  • b) teaching/scholarly activities,
  • c) supervision of graduate students and other research trainees,
  • d) grant applications.

The position comes with full salary but no bench fees; winning external funding is expected in this role.

As Postdoc/Team Lead, you will be expected to contribute to the management and performance of the Pediatric and Gastroenterology Department through participation at relevant meetings and taking on selected responsibilities relevant to the role (e.g. efficiency programs, recruitment of staff, facilities etc.). You will also be responsible for the leadership of project(s) and delivery on project objectives, maintaining an up-to-date understanding of scientific developments within the appropriate fields, and ensuring high standards are maintained at all programs.

The Project

The project will focus on intestinal immunology in neonatal/pediatric stages of life, with a particular interest in nutritional intervention studies, and the influences of microbial and metabolic activity on intestinal immune function. We aim to expand our understanding of complications of surgery, and immune-mediated intestinal disease, mostly in postsurgical human tissue.

We aim to focus on the cellular responses to an immune challenge to better understand the pathology of common intestinal complications after surgery, such as adhesions and fibrosis. The project will make use of state-of-the art in silico modelling, single-cell transcriptomics, and (Hyperion) mass cytometry as facilitated through Amsterdam University Imaging Center suites. Expert assistance is available to facilitate the complex technology platforms required for this work.

Your profile

Skill requirements:

Bioinformatic skills, optimally including demonstrable experience in in silico analysis and integration of omics data. You should also be skilled in visualizing and presenting data in an understandable fashion to (non-computational) biologists. Excellent communication skills in English.

Education:

PhD or MD/PhD in a relevant field, such as Bioinformatics, Systems Biology, Computer Science, Mathematics, Statistics, Biochemistry, Biology, or Human Genetics.

Work experience:

Applicants should be able to demonstrate excellent research achievements, a commitment to teaching and graduate training, and a strong track record in, and commitment to, interdisciplinary collaboration. The successful candidate will have a background that will allow him/her to successfully develop a dynamic and collaborative research program.

Your work environment

The Department of Pediatric Surgery and the Tytgat Institute of Liver and Intestinal Disease, at the Faculty of Medicine at the Amsterdam University Medical Centers, have formed a translational science unit merging Pediatrics and Gastroenterology. The successful candidate will show a strong commitment to facilitate integration of bioinformatic tools into other research lines within the institute.

We offer

Salary scale 10: €3580-4707 gross for full-time employment (depending on qualifications and experience).

  • We offer a contract for one year (12 months) with the prospect of a permanent contract.
  • In addition to a good basic salary, we offer an 8.3% end-of-year bonus and an 8% holiday allowance. Do you want to know what you will earn? Then calculate your net salary here (subject to change).
  • The successful candidate may be eligible for reimbursement of relocation expenses in accordance with University policy.

Amsterdam UMC has an open culture. This means that we hope that everyone feels welcome in our organization and that we strive to offer equal opportunities to everyone. We therefore cordially invite all interested parties to respond to this vacancy.

For more information about our terms of employment, please visit our website.

Let's meet

Please email a brief teaching statement and a description of your current and future research plans, along with your CV and three confidential letters of reference, to Prof. Wouter de Jonge (w.j.dejonge@amsterdamumc.nl) and Joep Derikx, Pediatric Surgeon, (j.derikx@amsterdamumc.nl).

For more information about this position, please contact Wouter de Jonge, subject line: Tytgat tenure – immune bioinformatics. For more information about the application procedure, please contact Joep Derikx.

Note: In the event of proven equal suitability, internal candidates may be given priority over external candidates.

Agency applications will not be considered.

Wouter J. de Jonge

w.j.dejonge@amsterdamumc.nl

Joep P.M. Derikx

j.derikx@amsterdamumc.nl