Address Amsterdam UMC
Department of Gastroenterology and Hepatology
Tytgat Institute for Liver and Intestinal Research
1105 BK Amsterdam
Caroline: +31 20 566 8156 Secretariat (Elsa): +31 20 566 5948
What we can do for your organisation
Gut Research is interested to supply customer-oriented consulting and contract research in the field of functional and inflammatory bowel diseases, as well as experimental models for medical nutrition formulae.
From its start, Gut Research will provide experimental models as a service basis to a number of academic, health and industrial institutions. Gut Research’s core activities have been essential in various international research projects and industrial research contracts.
Gut Research provides services to running models for drug/formulae testing, or microbial studies. Read outs include state of the art cell isolation, single cell Pro-seq workflows, biomarker finding, CyTOF or FACS sorting of targeted cells and behavioral studies related to IBD or IBS.
Gut Research scientists provide thorough consultation in the optimal setup of your experiments finding the appropriate analysis markers.
Our services and our experimental models
Our models focus around the fields of (with references to selected earlier published studies):
- Irritable Bowel Syndrome (IBS): visceral hypersensitivity and behavioral read outs. See articles on PubMed.
- Experimental colitis: acute and chronic colitis models, models for mucosal healing. See articles Genetic deletion of dectin-1 does not affect the course of murine experimental colitis and Selective alpha7 nicotinic acetylcholine receptor agonists worsen disease in experimental colitis.
- Functional bowel motility disorders: post-operative ileus, gastroparesis, anastomotic healing. See articles Inhibition of spleen tyrosine kinase as treatment of postoperative ileus, Mast cells trigger epithelial barrier dysfunction, bacterial translocation and postoperative ileus in a mouse model, Intestinal handling-induced mast cell activation and inflammation in human postoperative ileus and Neuroimmune mechanisms in postoperative ileus.
- Epithelial models for nutrition: primary epithelial systems of human and mouse origin to read out barrier function, inflammatory responses, or wound healing and differentiation.
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