What we can do for your organisation

Gut Research is happy to supply customer-oriented consulting and contract research in the field of functional and inflammatory bowel diseases, as well as experimental models for medical nutrition formulae.

From its start, and building upon the expertise of the founders and clinical associates, Gut Research will provide experimental models as a service basis to a number of academic, health and industrial institutions. Gut Research’s core activities have been essential in various international research projects and industrial research contracts.

Gut Research provides services to running models for drug/formulae testing. Read outs include state of the art cell isolation, biomarker finding, FACS sorting of targeted cells and behavioral studies, all for competitive charges.

Gut Research scientists provide thorough consultation in the optimal setup of your experiments finding the appropriate analysis markers.

Gut Research will provide experimental models as a service basis to a number of academic, health and industrial institutions

 

 

Interested?

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Our services and our experimental models

Our models focus around the fields of (with references to selected earlier published studies):

Irritable Bowel Syndrome (IBS)1-3
visceral hypersensitivity and behavioral read outs

Experimental colitis4,5
acute and chronic colitis models, models for mucosal healing

Functional bowel motility disorders6-9
post-operative ileus, gastroparesis, anastomotic healing

Epithelial models for nutrition
primary epithelial systems of human and mouse origin to read out growth and differentiation

References

1.     van den Wijngaard, R.M. et al. Essential role for TRPV1 in stress-induced (mast cell-dependent) colonic hypersensitivity in maternally separated rats. Neurogastroenterol. Motil. 21, 1107–e94 (2009).
2.     van den Wijngaard, R.M. et al. Peripheral α-helical CRF (9-41) does not reverse stress-induced mast cell dependent visceral hypersensitivity in maternally separated rats. Neurogastroenterol. Motil. (2011).doi:10.1111/j.1365-2982.2011.01840.x
3.     Stanisor, O.I. et al. Stress-induced visceral hypersensitivity in maternally separated rats can be reversed by peripherally restricted histamine-1-receptor antagonists. PLoS ONE 8, e66884 (2013).
4.     Heinsbroek, S.E. et al. Genetic deletion of dectin-1 does not affect the course of murine experimental colitis. BMC Gastroenterol 12, 33 (2012).
5.     Snoek, S.A. et al. Selective alpha7 nicotinic acetylcholine receptor agonists worsen disease in experimental colitis. Br. J. Pharmacol. 160, 322–333 (2010).
6.     van Bree, S.H.W. et al. Inhibition of spleen tyrosine kinase as treatment of postoperative ileus. Gut 62, 1581–1590 (2013).
7.     Snoek, S.A. et al. Mast cells trigger epithelial barrier dysfunction, bacterial translocation and postoperative ileus in a mouse model. Neurogastroenterol. Motil. (2011).doi:10.1111/j.1365-2982.2011.01820.x
8.     The, F.O. et al. Intestinal handling-induced mast cell activation and inflammation in human postoperative ileus. Gut 57, 33–40 (2008).
9.     Boeckxstaens, G.E. & de Jonge, W.J. Neuroimmune mechanisms in postoperative ileus. Gut 58, 1300–1311 (2009).