February 2018

June 2017

  • Irritable Bowel Syndrome is probably caused by fungi

    Patients with Irritable Bowel Syndrome (IBS) carry a different set of fungi in their gut compared to healthy people. This observed imbalance is related to abdominal pain complaints in IBS patients. This work was shown by researchers in The Netherlands which are based at Tytgat Institute (Academic Medical Center, Amsterdam), TNO (Zeist) and University of Maastricht.

    Until now IBS-related microbiome research almost exclusively focused on the bacterial composition of the gut. Recent investigations showed that the gut also harbors fungi, and this includes healthy people. New evidence now shows that the composition of gut fungi (the mycobiome) in IBS patients differs from healthy people. Fungal diversity as well as relative contribution of fungal species was altered. 

    A change in fungal composition was also observed in an often used IBS-like rat model, were stress induces abdominal pain. In this model, anti-fungals reversed abdominal pain and rat-to-rat poop transplantations showed that the fungal imbalance was relevant for abdominal pain. Earlier work showed that abdominal pain in IBS is induced by activation of mast cells, which are part of the immune system. The current investigations indicated that their activation is triggered by gut fungi. 

    ‘Obviously, this is not definitive proof for the role of fungi in IBS patients’ says René van den Wijngaard (Tytgat Institute) who headed the investigations. ‘But this study is an important reason to investigate further the possible role of fungi in IBS and search for new therapies that can modulate gut fungi or their interaction with the immune system’.

    IBS is a disorder where patients experience abdominal pain complaints with altered bowel habits (diarrhea or constipation) in the absence of structural or microscopic abnormalities. The worldwide prevalence of IBS is 10%. Since the exact triggers for abdominal pain complaints are unknown, there is no effective therapy at present time.

    More information can be found in the publication in Gastroenterology.

May 2017

  • Digestive Disease Week - Chicago

    Our team members Wouter de Jonge, Rene van den Wijngaard, Rose Willemze, Leonie de Vries, Emmeline Peters and Kay Diederen visited the Digestive Disease Week (DDW) in Chicago, IL. The congress was from May 6th-9th at the McCormick Place.

    Rose gave a poster presentation about Beta-blocker use in IBD.

    Kay gave four poster presentations about Fecal Amino Acids after EEN, Metabolic Changes after EEN, Fecal Calprotectin and Restorative Proctocolectomy and Ileal Pouch-Anal Anastomosis.

    Wouter presented the poster of Mohammed about the influence on HDAC3 on the Inflammatory Response.

    Leonie presented her research in the presentation “Oral Tyrosine Kinase 2 inhibitor ameliorates T cell transfer colitis”.

    And Rene gave a presentation entitled “Fecal transplantation and mycobiome analysis showing the relevance of fungi in post stress visceral hypersensitivity of maternal separated rats”.

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    For more information about the DDW in Chicago, click here.

February 2017

  • 12th ECCO Congress in Barcelona

    Team members Rose Willemze and Leonie de Vries will join the 12th Congress of the ECCO in Barcelona. Leonie will present her research entitled “Oral Tyrosine Kinase 2 inhibitor ameliorates T-cell transfer colitis” on a poster and Rose will present her research on two different posters entitled “Sympathetic but not vagal intestinal innervation regulates murine dextran sodium sulphate (DSS)-induced colitis” and “Beta-blocker use is associated with a higher relapse risk of inflammatory bowel disease – a Dutch retrospective cohort study”.

    For more information, please check the ECCO website.

  • Wouter de Jonge at "Proefkonijnen"

    Wouter de Jonge explained the mechanism of vomiting in the Dutch infotainment program “Proefkonijnen”. You can watch the program via the link. The part about vomiting starts around 24 minutes.

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January 2017

  • PhD defense of Shobhit Dhawan

    Our former team member Shobhit Dhawan defended his thesis entitled “Neural regulation of innate and adaptive immunity in the gut” with success on January 12th in Amsterdam.

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    The cover of his thesis was designed by Denis Roumegoux

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    Congratulations Dr. Dhawan!

  • Team building Curling

    On January 19th, the research team of Gut Research had a team building event. After drinks and some snacks, the team followed a curling clinic. The team building ended with a diner and drinks. This was all at the Jaap Edenbaan in Amsterdam.

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December 2016

  • Relation between postoperative ileus and anastomotic leakage after colorectal resection

    After bowel surgery, anastomotic sites (where the wound is stitched together) can sometimes leak, with dangerous consequences. The reason for leakage is not always clear, so it is difficult for a surgeon to circumvent it. Together with the Catharina Hospital in Eindhoven, we have now shown what can be an important reason of this leakage in a large patient trial. Read it in the publication of Emmeline Peters et al.

  • Mind, mood & microbes - 1st International Conference on microbiota-gut-brain axis

    On December 1st and 2nd, the 1st International Conference on microbiota-gut-brain axis was held in Amsterdam. Group leader Wouter de Jonge gave a presentation entitled “Gut feelings; molecular clues to a gut-brain axis”. 

    The conference summary and scientific report can be found on the conference website.

November 2016

  • Poster prize Andrew Li Yim

    From November 1st – 4th, the conference “Epigenomics in common diseases” was held in Hinxton. Andrew Li Yim, one of the ESRs of the European Epimac project, won a poster prize. More information can be found on the website of the conference.

October 2016

  • PhD defense Evelina Ferrantelli

    On October 6th, Evelina Ferrantelli defended her thesis entitled “Anti-inflammatory interventions and biomarker identification in peritoneal dialysis” succesfully. She did a great job and we’re really proud of her. Congratulations Evelina!

    promotie-evelina

  • RIP: Jeroen Oerlemans

    This weekend, we heard the sad news that fotographer Jeroen Oerlemans was killed in Syria. Jeroen was a freelance fotographer and covered several areas of conflict. In 2012, he was kidnapped for one week in Syria. His photographs are published in several well-known newspapers and Jeroen was awarded with the Silver Camera in 2008, 2010 and 2011.

    Besides the many photographs from abroad, he also made portrait photographs of individuals and groups. In 2013, Jeroen took pictures of our research group. His professional attitude was a joy to work with.

    We wish his wife, children, family and friends all the strength in these sad days.

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June 2016

  • A breakthrough collaboration of GSK and AMC on Bioelectronics for inflammation

    It is increasingly recognized that neuronal signals are critical players in shaping the immune response. Recent clinical trials have demonstrated therapeutic efficacy of electrical devices implanted to stimulate neuronal activity, to reduce inflammation.

    GSK Bioelectronics and AMC have now launched a 3-year collaborative program to establish the role of neuronal innervation in immune responses in chronic inflammatory disorders such as rheumatoid arthritis and inflammatory bowel disease. The project involves state of the art neuronal interfacing with the aim to establish the molecular mechanisms of neuro-immune interactions in the immune response, and enable clinical application of this technique.

    The 5FTE project team is funded by GSK Bioelectronics and closely collaborates with the Catharina Hospital in Eindhoven.

May 2016

February 2016

  • Innovation grant for MYCOMAP!

    Together with Descin, a science- and technology-driven innovator, Gut Research Services was awarded a 155k€ SME innovation grant by the ministry of economic affairs and regional government. The grant “MYCOMAP” is aimed at implementing a next generation sequencing facility pipeline to determine the composition of the microbial community.

    As Gut Research Services, we will be able to offer an easily accessible inventory of micro- and mycobiota -including complete biostatistical analyses- service for collaborations which may include industry, scientific, or lay parties.

    Any further information about this start up initiative can be obtained via our contact page.

January 2016

  • Microbiome Award

    PhD student and team member Sara Botschuijver won the Microbiome Award for her design of the Biotic comforter. For more information about her invention and the Microbiome Award, click on this link.

    Congratulations Sara!

    microbiome award Sara

October 2015

  • United European Gastroenterology week (UEGW) 2015

    Are you also joining the United European Gastroenterology week (UEGW) in Barcelona? Some of our team members will join this conference, so this is your chance to meet them and talk to them!

    For more information about the UEGW in Spain, click on this link.

September 2015

  • International Society for Autonomic Neuroscience (ISAN) 2015

    The International Society for Autonomic Neuroscience (ISAN) held  a meeting from September 26th until the 29th, in Stresa, Italy.

    Rose Willemze gave an oral presentation about the mesenteric nerve in experimental colitis and she had a poster about cholinergic Th17 cells.

    For more information about the ISAN meeting in Italy, click on this link.

    attending_poster_ISAN

May 2015

March 2015

  • Spring Meeting NVGE

    Did you also join the Spring Meeting of the NVGE on 19th and 20th March in Veldhoven? Our team members Sigrid Heinsbroek, Leonie de Vries and Nicolette Duijvis presented their work at the DEGH!

    To see the program of the Spring Meeting of the NVGE, click on this link.

February 2015

  • 10th Meeting of the European Crohn's and Colitis Organisation

    The 10th congress of the European Crohn’s and Colitis Organisation (ECCO) was held from 18th to 21st February in Barcelona, Spain. Several of our team members joined this congress.

    • Leonie de Vries had a poster entitled “Selective Janus Kinase 1 inhibitor targets monocytes and tissue macrophages during DSS colitis”.
    • Nicolette Duijvis had a poster presentation entitled “Lower long-term colectomy rates with IFX than with CsA treatment in moderate to severe UC” and was among the top 10 of the poster presentations.
    • Anje te Velde was awarded with an ECCO grant to study DNA methylation profiles in IBD fibroblasts.

    Congratulations Nicolette and Anje with this great achievement!

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    To read more about the 10th ECCO congress, click on this link

January 2015

  • Thesis defence of Léa Costes

    On January 23rd, Léa Costes defended her thesis entitled “Neuromodulation of intestinal inflammation” succesfully at the Agnietenkapel in Amsterdam.

    To read about the thesis, please click here.

    Congratulations Lea!

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December 2014

  • Thesis defence of Bram van Rhijn

    On December 3rd, Bram van Rhijn defended his thesis entitled “Eosinophilic esophagitis: studies on an emerging disease” succesfully at the University of Amsterdam.

    To read about the thesis, please click here.

    Congratulations Bram!

October 2014

  • 9th European Mucosal Immunology Group Meeting

    The 9th meeting of the European Mucosal Immunology Group (EMIG) was this year from 9th to 12th October in Glasgow, Scotland. Sigrid Heinsbroek, one of our team members, gave a presentation entitled “miR511-3p located within MR gene contributes to intestinal inflammation by regulating TLR4 levels”.

    To read more about the EMIG2014, click on this link.

May 2014

  • Thesis of Oana on the Dutch website www.darmgezondheid.nl

    On May 28th the Dutch website www.darmgezondheid.nl published about the thesis of Oana Ingrid Stanisor. She defended her thesis in April. To read about the thesis on the website, please click here.

April 2014

  • Electrical stimulation of nerves in the Dutch TV program "Kennis van Nu".

    On April 27th the Dutch TV program “Kennis van Nu” was broadcasted with an item about electrical stimulation of nerves. You can watch it by clicking here.

  • Thesis defence of Oana Stanisor

    On April 29th, Oana Stanisor defended her thesis titled “Pathophysiology  of stress-induced visceral hypersensitivity” in the Agnietenkapel in Amsterdam. If you’re interested in her thesis, you can read it here.

March 2014

  • Nerve stimulation to decrease inflammation

    A nice interview with Wouter de Jonge for the Dutch website “Medisch Contact”.

    To read the interview, please click here (Dutch).

February 2014

  • Inaugural lecture of Wouter de Jonge

    February 20th, Wouter de Jonge held his inaugural lecture in the Lutheran Church in Amsterdam.

    To read about his lecture, please click here (Dutch).

December 2013

  • GSK Bioelectronics meeting in New York City

    Wouter de Jonge and Cathy Cailotto attended the GSK Bioelectronics meeting in New York City on December 16th & 17th.

For more information about GSK Bioelectronics, watch this video

For more information about the experiences of the participants about the meeting in New York City, watch this video

October 2013

  • United European Gastroenterology Week in Berlin

    Shobhit Dhawan attended the United European Gastroenterology Week in Berlin and presented his latest studies on the effect of stress on intestinal immunity.

  • GSK Bioelectronics is funding

    GSK Bioelectronics is funding a project around specific stimulation of nerves to modulate inflammation! The Kick-off meeting was held on October 3rd.

  • Publication in Gastroenterology

    The collaborative study on the role of enteric glial cells, a kind of neuronal support cells, in inflammation due to surgery was published in Gastroenterology! Congrats to all authors.

  • GSK collaborative clinical and lab study

    A GSK collaborative clinical and lab study in ulcerative colitis patients was headed off. The efficacy of a novel anti-inflammatory agent will be studied in clinical trial and biomarker analyses study.

September 2013

  • Olaf Welting

    Olaf Welting became father and his life will never be the same.

August 2013

  • Francisca Hilbers

    Francisca Hilbers got married to Sander van Leeuwen!