End meeting of the EPIMAC project
On July 10th, the people involved in the EPIMAC project were at the end meeting at GSK in Stevenage, UK. All the ESRs gave a presentation of their projects with the last results. The fruitfull collaboration was ended with a dinner.
PhD defense Sophie van Diest
On June 25th Sophie van Diest defended her thesis entitled “The pain behind visceral hypersensitivity in irritable bowel syndrome (IBS)” in the Agnietenkapel in Amsterdam with success. Well done Sophie!
PhD defense Rose Willemze
Rose Willemze defended her thesis with the title “Connecting innervation and intestinal inflammation” in the Old Lutheran Church in Amsterdam on June 28th with great success. Congratulations Rose!
On February 11th, the pre-kickoff meeting of the GROWTH consortium was held in Amsterdam.
The GROWTH consortium, funded by the European Commission (2019-2023), is made up to train a new generation of researchers working on new pathological insights, biomarker diagnostics and personalized nutritional interventions for intestinal failure in neonates and preterm infants.
More information about the GROWTH consortium and the different projects can be found on the GROWTH website,
Always wanted to meet the people of Gut Research? Get that chance at one of the following events!
The people from Gut Research will be at the Keystone Symposium Regulation and dysregulation of innate immunity in disease from February 18-22 in Vancouver, British Columbia, Canada.
They will also be at the following events:
Hope to see you there!
Patients with Irritable Bowel Syndrome (IBS) carry a different set of fungi in their gut compared to healthy people. This observed imbalance is related to abdominal pain complaints in IBS patients. This work was shown by researchers in The Netherlands which are based at Tytgat Institute (Academic Medical Center, Amsterdam), TNO (Zeist) and University of Maastricht.
Until now IBS-related microbiome research almost exclusively focused on the bacterial composition of the gut. Recent investigations showed that the gut also harbors fungi, and this includes healthy people. New evidence now shows that the composition of gut fungi (the mycobiome) in IBS patients differs from healthy people. Fungal diversity as well as relative contribution of fungal species was altered.
A change in fungal composition was also observed in an often used IBS-like rat model, were stress induces abdominal pain. In this model, anti-fungals reversed abdominal pain and rat-to-rat poop transplantations showed that the fungal imbalance was relevant for abdominal pain. Earlier work showed that abdominal pain in IBS is induced by activation of mast cells, which are part of the immune system. The current investigations indicated that their activation is triggered by gut fungi.
‘Obviously, this is not definitive proof for the role of fungi in IBS patients’ says René van den Wijngaard (Tytgat Institute) who headed the investigations. ‘But this study is an important reason to investigate further the possible role of fungi in IBS and search for new therapies that can modulate gut fungi or their interaction with the immune system’.
IBS is a disorder where patients experience abdominal pain complaints with altered bowel habits (diarrhea or constipation) in the absence of structural or microscopic abnormalities. The worldwide prevalence of IBS is 10%. Since the exact triggers for abdominal pain complaints are unknown, there is no effective therapy at present time.
More information can be found in the publication in Gastroenterology.
Our team members Wouter de Jonge, Rene van den Wijngaard, Rose Willemze, Leonie de Vries, Emmeline Peters and Kay Diederen visited the Digestive Disease Week (DDW) in Chicago, IL. The congress was from May 6th-9th at the McCormick Place.
Rose gave a poster presentation about Beta-blocker use in IBD.
Kay gave four poster presentations about Fecal Amino Acids after EEN, Metabolic Changes after EEN, Fecal Calprotectin and Restorative Proctocolectomy and Ileal Pouch-Anal Anastomosis.
Wouter presented the poster of Mohammed about the influence on HDAC3 on the Inflammatory Response.
Leonie presented her research in the presentation “Oral Tyrosine Kinase 2 inhibitor ameliorates T cell transfer colitis”.
And Rene gave a presentation entitled “Fecal transplantation and mycobiome analysis showing the relevance of fungi in post stress visceral hypersensitivity of maternal separated rats”.
For more information about the DDW in Chicago, click here.
Team members Rose Willemze and Leonie de Vries will join the 12th Congress of the ECCO in Barcelona. Leonie will present her research entitled “Oral Tyrosine Kinase 2 inhibitor ameliorates T-cell transfer colitis” on a poster and Rose will present her research on two different posters entitled “Sympathetic but not vagal intestinal innervation regulates murine dextran sodium sulphate (DSS)-induced colitis” and “Beta-blocker use is associated with a higher relapse risk of inflammatory bowel disease – a Dutch retrospective cohort study”.
For more information, please check the ECCO website.
Our former team member Shobhit Dhawan defended his thesis entitled “Neural regulation of innate and adaptive immunity in the gut” with success on January 12th in Amsterdam.
The cover of his thesis was designed by Denis Roumegoux
Congratulations Dr. Dhawan!
On January 19th, the research team of Gut Research had a team building event. After drinks and some snacks, the team followed a curling clinic. The team building ended with a diner and drinks. This was all at the Jaap Edenbaan in Amsterdam.
After bowel surgery, anastomotic sites (where the wound is stitched together) can sometimes leak, with dangerous consequences. The reason for leakage is not always clear, so it is difficult for a surgeon to circumvent it. Together with the Catharina Hospital in Eindhoven, we have now shown what can be an important reason of this leakage in a large patient trial. Read it in the publication of Emmeline Peters et al.
On December 1st and 2nd, the 1st International Conference on microbiota-gut-brain axis was held in Amsterdam. Group leader Wouter de Jonge gave a presentation entitled “Gut feelings; molecular clues to a gut-brain axis”.
The conference summary and scientific report can be found on the conference website.
From November 1st – 4th, the conference “Epigenomics in common diseases” was held in Hinxton. Andrew Li Yim, one of the ESRs of the European Epimac project, won a poster prize. More information can be found on the website of the conference.
On October 6th, Evelina Ferrantelli defended her thesis entitled “Anti-inflammatory interventions and biomarker identification in peritoneal dialysis” succesfully. She did a great job and we’re really proud of her. Congratulations Evelina!
This weekend, we heard the sad news that fotographer Jeroen Oerlemans was killed in Syria. Jeroen was a freelance fotographer and covered several areas of conflict. In 2012, he was kidnapped for one week in Syria. His photographs are published in several well-known newspapers and Jeroen was awarded with the Silver Camera in 2008, 2010 and 2011.
Besides the many photographs from abroad, he also made portrait photographs of individuals and groups. In 2013, Jeroen took pictures of our research group. His professional attitude was a joy to work with.
We wish his wife, children, family and friends all the strength in these sad days.
It is increasingly recognized that neuronal signals are critical players in shaping the immune response. Recent clinical trials have demonstrated therapeutic efficacy of electrical devices implanted to stimulate neuronal activity, to reduce inflammation.
GSK Bioelectronics and AMC have now launched a 3-year collaborative program to establish the role of neuronal innervation in immune responses in chronic inflammatory disorders such as rheumatoid arthritis and inflammatory bowel disease. The project involves state of the art neuronal interfacing with the aim to establish the molecular mechanisms of neuro-immune interactions in the immune response, and enable clinical application of this technique.
The 5FTE project team is funded by GSK Bioelectronics and closely collaborates with the Catharina Hospital in Eindhoven.
From May 21st until 24th, the annual Digestive Disease Week was held. The location this year was in the San Diego Convention Center in San Diego, California. Our team members Emmeline Peters, Leonie de Vries, Rose Willemze and Kay Diederen presented their research. Did you miss them? Don’t worry, you can still see their research by clicking on the links.
Leonie de Vries:
Together with Descin, a science- and technology-driven innovator, Gut Research Services was awarded a 155k€ SME innovation grant by the ministry of economic affairs and regional government. The grant “MYCOMAP” is aimed at implementing a next generation sequencing facility pipeline to determine the composition of the microbial community.
As Gut Research Services, we will be able to offer an easily accessible inventory of micro- and mycobiota -including complete biostatistical analyses- service for collaborations which may include industry, scientific, or lay parties.
Any further information about this start up initiative can be obtained via our contact page.
PhD student and team member Sara Botschuijver won the Microbiome Award for her design of the Biotic comforter. For more information about her invention and the Microbiome Award, click on this link.
Are you also joining the United European Gastroenterology week (UEGW) in Barcelona? Some of our team members will join this conference, so this is your chance to meet them and talk to them!
For more information about the UEGW in Spain, click on this link.
The International Society for Autonomic Neuroscience (ISAN) held a meeting from September 26th until the 29th, in Stresa, Italy.
For more information about the ISAN meeting in Italy, click on this link.
This year, the Digestive Disease Week (DDW) was held in Washington, DC at the Walter E. Washington Convention Center.
Some of our team members presented their work over there.
Rose was awarded as one of the Winners of the Day 4 Poster Competition. Congratulations!!
Click on the link, if you’re interested in their work.
For all the people who don’t have the opportunity to join the DDW this year, the AMC presents the “DDW highlights symposium” on Thursday 28th of May in Amsterdam. The latest scientific developments in the field of IBD, colorectal cancer, esophageal pathology and HPB will be presented then.
In addition, state of the art lectures are given by Prof. Dr. G. D’Haens and Dr. A. Bredenoord.
You can register for the symposium via this form.
Did you also join the Spring Meeting of the NVGE on 19th and 20th March in Veldhoven? Our team members Sigrid Heinsbroek, Leonie de Vries and Nicolette Duijvis presented their work at the DEGH!
To see the program of the Spring Meeting of the NVGE, click on this link.
The 10th congress of the European Crohn’s and Colitis Organisation (ECCO) was held from 18th to 21st February in Barcelona, Spain. Several of our team members joined this congress.
Congratulations Nicolette and Anje with this great achievement!
To read more about the 10th ECCO congress, click on this link
On January 23rd, Léa Costes defended her thesis entitled “Neuromodulation of intestinal inflammation” succesfully at the Agnietenkapel in Amsterdam.
To read about the thesis, please click here.
On December 3rd, Bram van Rhijn defended his thesis entitled “Eosinophilic esophagitis: studies on an emerging disease” succesfully at the University of Amsterdam.
To read about the thesis, please click here.
The 9th meeting of the European Mucosal Immunology Group (EMIG) was this year from 9th to 12th October in Glasgow, Scotland. Sigrid Heinsbroek, one of our team members, gave a presentation entitled “miR511-3p located within MR gene contributes to intestinal inflammation by regulating TLR4 levels”.
To read more about the EMIG2014, click on this link.
On April 29th, Oana Stanisor defended her thesis titled “Pathophysiology of stress-induced visceral hypersensitivity” in the Agnietenkapel in Amsterdam. If you’re interested in her thesis, you can read it here.
Wouter de Jonge and Cathy Cailotto attended the GSK Bioelectronics meeting in New York City on December 16th & 17th.
Shobhit Dhawan attended the United European Gastroenterology Week in Berlin and presented his latest studies on the effect of stress on intestinal immunity.
GSK Bioelectronics is funding a project around specific stimulation of nerves to modulate inflammation! The Kick-off meeting was held on October 3rd.
The collaborative study on the role of enteric glial cells, a kind of neuronal support cells, in inflammation due to surgery was published in Gastroenterology! Congrats to all authors.
A GSK collaborative clinical and lab study in ulcerative colitis patients was headed off. The efficacy of a novel anti-inflammatory agent will be studied in clinical trial and biomarker analyses study.
Olaf Welting became father and his life will never be the same.
Francisca Hilbers got married to Sander van Leeuwen!