Esophageal diseases

The esophageal diseases team of the AMC focusses both on prevalent and rare benign esophageal diseases, such as achalasia, eosinophilic esophagitis and gastroesophageal reflux disease. There is a strong link between the clinic and the lab, resulting in state of the art clinical care and research.


Achalasia is a rare disease of unknown cause, leading to destruction of nerves in the esophageal wall. The AMC hosts the largest population of achalasia patients in the Netherlands. A joint medical-surgical clinic is available to evaluate patients that require complex care. Research focusses on pathophysiology, involving experimental studies on the role of antibodies in this diseases. Ongoing diagnostic research aims to improve diagnostic characteristics of new and existing techniques. The team from the AMC coordinates large international randomized controlled trials to investigate the efficacy of new treatments, involving centers from Europe, Asia and North America.

Esophageal diseases

Eosinophilic esophagitis

Eosinophilic esophagitis (EoE) is an inflammatory disease of the esophagus, leading to fibrosis and narrowing of the esophageal lumen. There is a huge increase in incidence over the last 15 years. Both studies on the pathophysiology as well as clinical phase II and III trials are performed in the AMC. Pathophysiological studies focus on the role of acid reflux and mucosal permeability changes in EoE. Clinical trials include farmaceutical trials as well as dietary intervention studies.

Gastroesophageal reflux disease

Gastroesophageal reflux disease (GERD) is one of the most prevalent chronic diseases, affecting 15-20 % of the population. For over twenty years a strong focus on GERD is present in the AMC, inclusion a multidisciplinary clinic run by a surgeon and gastroenterologists and a strong research program covering a possible aspects of the disease. Clinical research includes phase I, II and III clinical trials, as well as epidemiological studies and pathophysiological studies. Pathophysiological studies are performed in the Tytgat institute and focus on the role of mucosal integrity in GERD, using human and animal tissue. Animal models are used to investigate the role of stressors.

There is a strong link between the clinic and the lab, resulting in state of the art clinical care and research.