Eosinophilic esophagitis (EoE) is an inflammatory disease of the esophagus, leading to fibrosis and narrowing of the esophageal lumen. There is a huge increase in incidence over the last 15 years. Both studies on the pathophysiology as well as clinical phase II and III trials are performed in the AMC. Pathophysiological studies focus on the role of acid reflux and mucosal permeability changes in EoE. Clinical trials include farmaceutical trials as well as dietary intervention studies.
Gastroesophageal reflux disease
Gastroesophageal reflux disease (GERD) is one of the most prevalent chronic diseases, affecting 15-20 % of the population. For over twenty years a strong focus on GERD is present in the AMC, inclusion a multidisciplinary clinic run by a surgeon and gastroenterologists and a strong research program covering a possible aspects of the disease. Clinical research includes phase I, II and III clinical trials, as well as epidemiological studies and pathophysiological studies. Pathophysiological studies are performed in the Tytgat institute and focus on the role of mucosal integrity in GERD, using human and animal tissue. Animal models are used to investigate the role of stressors.